Don't give up on the 100gr Barnes TTSX's. They are very, VERY deadly little pills in a 25 ROY. Not as high of a BC as the other two you mention, of course, but out to 500 yards or a bit more they are hard to beat. My longest shot with them was last October, 618 yards on a good sized Mule Deer buck, and the Bullet performed as good as one could hope at that range and a 25 caliber of any stripe.
So far my go to powder has been RL-22, but with my new barrel being a 28 inch job I am going to give RL-25 a shot this year and see if it is an improvement in velocity or accuracy.
Last edited by safariman; 04/15/14.