I have....on several deer.
They work! I've never caught one yet. The longest shot I've taken with them is 150ish and I've killed a couple pretty heavy bucks with them. The first one below was shot head on and the bullet exited the flank. The second one was a true broadside shot. Neither deer went far. I've had others drop in their tracks, while the farthest death run was about 80 yards.