The rate of twist of your rifle will dictate how well they shoot, for the most part. Those Hornady bullets need 1-10" or better for optimal stability. I used them for years in .30/40 Krags, 1-10" twists, driven at 1900 or so fps (before I wised up and switched entirely to 210 grain cast in them). I would at least try them in the Savage for sh*ts and giggles, you never know. Only down side is they will intrude waaaay down into the case past the neck, dramatically reducing powder capacity. I got decent accuracy in my M1920 .300 with the 210 cast bullets, but not as good as with 160-180's so I dropped the heavies before devoting too much time to the experiment.
If you're looking for a bullet that'll rake through a Mastodon from end-to-end and stay together in the process, that Hornady 220 is your huckleberry!
While being a superb round, the .300 does have a few limitations.
I drew an area 7 mastadon tag this year. It should be perfect for the 22 HP.
