The possibility of deer running off some of the property we have permission to hunt or even running far enough for another hunter to shoot and claim are very real here in WV. So far for the last 35+ yrs I've found a shot that disrupts the central nervous system puts them down the quickest. The high shoulder shot mentioned earlier is my favorite if I need that reaction. Chambering so far to me hasn't seemed to matter. I like the heavy for caliber bullets,talking cup and core,in chamberings under .308 caliber. Any ones above that,for example the 270gr Speer in my 9.3x62,and the bullet choice so far hasn't seemed to matter. Since I do my own processing and don't like to waste meat so I'd rather the bullet not be too destructive.

Of course you're talking elk and even though they're anatomically alike to deer the results I get and that you need will need some input from those with experience hunting them.