In the Console of my F-150, rides a Glock 31 in 357sig with a Surefire Lazer / Light Combo mounted on it. And 5 extra 15 round mags.
In the side pouch on the driver side door, is a S&W Governor in 45 / 410.
First round is a 2.5" .410 skeet load with # 9 shot, and the next 5 rounds are 250gr Speer Golddot HP 45 Colt rounds.
The .410 is for killing Rattlesnakes at the Ranch, which is usually at night when I get out to open the gate.
And of course, a .556 AR-15, laying in the back seat for Hogs, Coyotes, or Cans