Unless you make the mistake of thinking pronghorns are antelopes which they are not the 50 BMG is used less in antelope country than the 12.7x108. Folks who use them have made their choice.

In the Middle East antelope country (Oryx is not just a trademarked bullet) the 12.7x108 on Toyota 4X pickup trucks is a choice rig. Same in Tibet. See e.g.
Quote
Kekexili: Mountain Patrol is the sophomore effort of Chinese director Chuan Lu. This film is, in effect, a Western shot in the steppes of Tibet. Only instead of trying to save the ranch, the heroes are trying to preserve the Tibetan antelope in the face of poachers. Shot documentary style, this film is a fictional narrative set against a backdrop of actual events.
National Geographic level scenery.

If the 12.7x108 didn't exist I don't doubt the 50 BMG would work but the 12.7x108 is in line with today's bigger is better and shots at ever longer ranges are fashionable craze.