I wouldn't.
Are the extra long, scoped hand cannons accurate? You bet.
njs1230 here has shot deer beyond 100 yards with both the Dan Wesson 445 SM and 357 SM (357 Maximum). He was happy to do so, but it required a lot of practice with some pretty nasty loads to get proficient at the 100-150 yard mark; he was great at 200 yards, but considering what resting equipment was lugged into the field, it could have been and eventually now is avoided.
He now carries a Traditions MZ and has complete confidence.
If the deer are inside 100 yards, I have seen and have done as well with scoped, unwieldy handguns versus our rifled barreled, saboted slug loads.
The saboted and un-saboted scoped MZ's do 100 without a trick and go beyond with miles less coddling than either. Perhaps its x's 2 over any longish, scope sighted handgun in legal cartridges here.
If we had the straightish walled, lever gunned repeaters, we might be able to eclipse the "automatic Bambi" feeling of the inline pseudo MZ.....
