For deer, antelope and miscellaneous medium size critters I use factory loads Federal Premium 30-06, 150 grain Sierra Game King BTSP at 2,910fps. Real accurate in my rifle.
For larger critters I use 180 grain Nosler Partitions with Spitzer points, 61 grains RL22, 2,880 fps. The trajectories are close enough that I can switch loads without adjusting my scope.
Actually I have pretty much stopped using the 150s because I bought a new 25-06 that I love.
KC