I used a 22-250 for 5 or 6 seasons loaded with 60 grain Nosler Partitions and never once felt undergunned. All of my deer were shot from 15 yards to 150 yards. Probably shot 15 deer and had only 1 run over 50 yards with most making it less than 15 yards. I often think about going back to it as the farm my dad purchased has deer that rarely go over 150 lbs. on the hoof and don't require much horsepower to punch through. Only thing I did notice with the Partition was the lack of blood on the ground on deer that traveled any distance at all even though I watched all but that 1 deer go down, I want to see more blood in case an animal does do a bit of traveling or gets in thick brush.
