Yeah, for general hunts I've used variable scopes up to 3-9x on my .375's.
Good to know, JB! I'm slated for Zimbabwe next August, combination Cape buff and plains game. I'm planning to take my 375 Ruger African as my sole rifle and shoot everything with it. I have it scoped currently with a Leupold 2.5-8X VX-3, which I figured will work for longer shots on the light stuff and close-in work for buff.
