222ND,
I tried a bunch of powders in the .22-250 a year or so ago, and my rifle just happens to be a Savage with a 22" barrel. CFE223 turned out to be the velocity champ with the approximate bullet weight you're interested in, with 40.0 grains getting 3951 fps with the 50-grain V-Max and 39.0 grains getting 3801 with the 53 TSX. Accuracy was good with both loads as well.
