I wouldn't think there would be much difference in performance. I have a 6.5X06 that was just a deal as it came with dies, brass, a custom barrel, custom trigger etc. I've been using the 125 Partition and it has 2-whitetails to it's credit. I might switch to a 140 next year and see if there's less meat damage. Both deer dropped in their tracks. I made up the brass from various .30-06 (including some L.C. 68 stuff) and no neck turning required. I have also used .25-06 & .270 with no problems. Seems the .30-06 got a little shorter? 1/2" to 1" groups. I like it as brass is so easy to come by. Just my 2�.