I freely admit that I am not a rifle loony. I am a hunter that shoots, not a shooter that hunts. My reasons for venturing into 25-06 :
1) I'm 56 and one of these days recoil is going to start bothering me. I therefore resolved to buy one more 30-06 and then start investigating smaller calibers. In that respect, 25-06 was a good first step.
2) I don't do a whole lot of varminting, and most of what I've done in the past has been with 22LR and 223 REM. 25-06 seemed like a good varmint/deer chambering. I have killed coyote before, but always as a target of opportunity.
3) My buddy had this custom 25-06, that he'd hunted with for 30-some years. He went blind at 84, and had to give it all up. I bought the rifle so it would have a good home, and I did not quibble on the price.
4) I don't have to reduce the powder all that much and I'm down into 257 Rob levels. It is always easier and safer to load down as to try and force it and load up.
