I ran golden sabers in all cartridges 230 grain 45acp, 180 grain in the 40 and I think 124 in the 9mm. Deer shot with the 9 never acted like they were hit and ran on average 75 yards before running into the ground, and a couple required follow up shots. A couple were hit in the shoulder and still didn't show signs of being hit until they fell. The 40s seem to hit harder and the deer showed it but most ran over 50-75 yards. I had to follow up one with the 40 after a spine shot but I've had to do that before with a 7 mag. The 45 took a couple off their feet immediately that were hit in a shoulder and lung shots ended in 25-40 yard runs and they struggled to make it that far. Never needed a follow up shot with the 45.