A few Summers ago, I killed 2 Coyotes about 3 weeks apart with my S&W Model 66 which happened to be the closest thing to a Coyote gun that I had with me at the time. The bullet was a 140 Nosler JHP pushed along by a large dose of H110.

First one was at about 30 yards and it died fairly quickly (after 2 hits).

Second one was farther and I had a hard time putting him down --finally did about the time the gun ran dry. Not what I like to see. I've carried a .223 in the truck ever since.