I like to use my 7x57 with 175 heavies....can eat up to the wound channel. Them .270 are one shot wonders and will put the boots to most anything you hit properly. Caribou are like rabbit, pretty thin skinned and light meat/tissue density. They will run far when hit wrong, I've used many .270's so much in the past years I have nothing but praise for that caliber but as far as Grizzlies go I prefer bigger/heavier bullets, I like how they work on big Grizz. Have fun.