I have used the 150 E-Tip quite extensively on both Alaskan Deer and Goats as well as African Plains Game up to Eland (inc. Wildebeest, Zebra, etc.)
My load was as follows:
72.5 gr. of Ramshot Magnum, 150 E-Tip loaded 3/100's off the lands. 3,000 fps from a 24" barrel. (*book max, 73.2gr.)
My groups were in the 1/2-3/4" at 100, 1.5" at 200 yards.
I had full penetration on 550# Wildebeest and the Zebra stopped the bullet in the far off shoulder after 30" of penetration.
The recovered bullet was textbook perfect.