I've owned a 480 SRH with a set of Crimson Trace laser grips and they SUCK big time. If you hate your middle finger then you won't mind losing it after shooting a few rounds through your 480 wearing laser grips. The Crimson Trace laser grips are awful for such a heavy-recoiling round. I have used them on lesser revolvers and like them a lot - just not on anything that kicks.
I actually wrote a letter to CT asking them to make a better set of grips that handle recoil. They won't so that's why the laser on a rail.