There's culls, and then there are culls. I've done buffalo hunts that the 5 Kilos is plenty, which would be just about all of them. I've also travelled with a pile of .458 component bullets and brass and a hand-press, and loaded with ADI powder and locally bought primers at that end. That was a crazy trip and probably couldn't be repeated today; but tomorrow who knows? For more general feral shooting my technique was to have an Australian enthusiast load a couple thousand rounds for me, but a common caliber and a few cases of blue box Federal would work too.
Culling is situational. Nobody is very eager to leave a severe problem going for years anymore, you need to whip in a few steps ahead of the choppers and the CPM club.
Life begins at 40. Recoil begins at "Over 40" Coincidence? I don't think so.