For tough game, Barnes is at least around while Nosler seems to haz the gay for now. Otherwise there are the usual suspects for cup n cores, I like speer over hornady myself. It really depends on what you want to hunt and how selective you are willing to be with shots. If it's just deer or similar, even the 150's will be fine. For reference, I took a mule deer using the 150 hot core at a fairly steep angle... he collapsed on impact, twitched and expired. That bullet was going 3200 from the muzzle (hotter than desired but it's what I had). Terminal performance was three broken ribs, his upper liver volcano'd back out the entrance hole, a raked backstrap / spinal column pierced and exited at one point, a smashed his pelvis and femur before the core came to a stop somewhere around his hip socket. External ballistics for that load closely mirrors Hornady's American Whitetail 7 RM, 139 gr SPFB IIRC.
