The most explosive 6mm varmint bullet is the 62 grain Barnes Varmint Grenade - period. They need a twist in the 1:10 range, because they are as long as 80-87 grain offerings. Most .243's should work. I haven't used them on yotes, but the advertisements say they enter with a tiny hole then explode inside without exiting.
Here is a photo of the destruction caused by the closest Varmint Grenade I have pictures for, the 50 grain .224 on a ground squirrel. The yellow arrow points to the remaining ear.
The rest of the squirrel vanished. If you really want explosive expansion the copper-tin powdered metal core of the Varmint Grenade will deliver.