Shooting 140 SST's and 140 VLD's, Vv N165 was one of the most accurate powders. I tried it, based on the recommendation of my smith who told me that some of the top LR competitive shooters liked it. The accuracy node was at 2,950 fps.
I recently started using RL-17 and can push 140's to 3,000 fps without giving up much in the way of accuracy. This gun, a custom pre-64, blueprinted with Borden's Bumps and a 26" sporter weight Kreiger will group 4 1/2" at 600 yds. It's a bit over 9#'s with a Z5 3.5-18x44 BT and Outdoorsmans turret set up for this load. Ideal combo for whitetails, pronghorns and hogs.
DF