I bought a 4" model Python in the late 80's; it had some finish wear, but timed and shot very well. I wasn't shy about loading it heavy, either, with 125gr JHP's and Blue Dot (not now recommended) but it seemed to take the loads in stride. I think I paid about $400 for it. The same gun now would probably be at least $1k, and maybe more
I'm not sure they were of the same quality by the 1980's, that they were in the 60's and 70's. In their prime, they unquestionably were beautiful guns, with gorgeous finishing, elegant design, smooth actions, and excellent accuracy. The design unquestionably influenced the styling of other guns, like Dan Wesson, and the full-lug Smiths. Besides the unique action, there were stories about the barrels being slightly tapered, from cylinder to muzzle, which was said to enhance accuracy. I never owned a 6 or 8" model, so I really could not compare its accuracy to my S&W's, or to a Dan Wesson.
Ayoob reported he'd heard of them breaking lockwork, in gunfights, when the owner was firing DA as fast as he could, putting a lot of stress on the action. Also, it's not easy to find good grips for them, IME.
If I could find a 6" under $1k, in good mechanical shape, it would be interesting to try it for accuracy. And if I lucked into a mint early gun at a good price, I'd sure keep it for investment's sake, but otherwise, yeah I agree with folks they are over-priced for what they are. You can buy a damn nice N frame for a lot less than a Python.