Mac,
Complete penetration / shot through Nilgai, large feral hogs, whitetail, red deer, etc.
I use them in my .405 Miroku1895 and .405 Simson double rifle. Velocity 2250 fps with hand loads.
I use other ammo also, but no time for details.
I will use them in my 45-70 double if needed, but no reason to waste expensive 45-70 ammo on deer and hogs. 300 grain JSP at 1500+ fps dump all medium sized "big" game nicely, including this 300 pound boar: