I have killed dozens of caribou with the semi-pointed version of the 100 Pro-Hunter via a M788 6mm. I think I recovered a single one, or parts of one anyway. None of those bullets remotely failed to do the job swiftly and humanely. A better bullet, if you need one, is the 95 Partition - or the 100 NPT if it shoots for you.

Sometimes, the air you 'let in'matters less than the air you 'let out'.