If a cartridge / bullet combination fails to penetrate deeply enough from any angle needed to hit the vitails then it failed. If the bullet reaches the heart and the advasary continues on, instead of instant incapacitation that is simply the difference from one to another and no fault of the cartridge load combination, because it did the damage. This applies to rifle, shotgun and handgun.
I basically agree.
But 'more than enough' gun, applied well and liberally, tends to make this a rare occurrence.
