Used the 375 for many years, killed moose, deer and brown bear. When winchester dropped the 250PP couldn't find a suitable replacement so switched to 356. Recently picked up a NIB top eject 375 for 550.00 couldn't pass that up. For me the 200gr bullet never grouped well, the 220 hornady;s came apart on a black bear, planning now to pick up the kodiak 255 38.55 bullet and re-size them down to .375. Always used re-7 when loading for the 375. When reloading the 255's plan on re-7 but will try out imr4198 see which has best velocity/accuracy.