Depends on what you want the gun to do. In my experience with a 243 if you shoot the heavy bullets like 100 grain sierra gamekings and 105 bergers the damage is minimal and is only an in and out with no significant exit damage. I built a 204 a couple years ago that i had throated and twisted to shoot the 55 grain bergers and its great in the wind and will shoot those at about 3250 out of a 24" barrel. This setup shoots well and and does minimal damage.
22-250 and 220 swift work extremely well and knock coyotes dead with authority but if you want to save the pelt bullet selection is critical.
