Don't know about the rest of North America, only have bush experience in BC and Alberta and a bit in Canada's northern territories.

I am often solo, usually by choice and am currently enamoured of a Kimber MA in 280AI, using 160NPs over 65-MagPro.

However, I would choose one of my .338WMs with 250NPs over 76-RE-22 and I always take a .338 on any hunt. now usually one of my Dakota 76s in synthetic handles.