I have a 12FV .22-250 that gets used on Idaho ground squirrels. Mine keyholes with some 55 grainers, like Sierra, so I have been shooting 40 gr. ballistic tips at 4000 fps. This combo has recorded hits at over 400 yards. That is with zero wind. I have been developing a load with a 50 gr. Midway Dogtown that is showing potential.

One thing with the .22-259, you have to discipline yourself to keep the barrel from melting down. I generally bring a .223 and a .22 rimfire too and switch off.

The 12FV is a good rifle, but there are a few things I don't like. First, the stock that comes with it is garbage. I put a Bell and Carlson on mine. The other thing is that the throat is very long. I can't get a 40 gr. ballistic tip anywhere near the rifling. Even so, it can put 5 rounds in a half inch @ 100 yards.

My scope is a Burris 4.5-14X50.