Col. Pickett used that bullet in his 45/110 for grizz. he said it made grizz hunting a one shot kill affair. The 330 grain express slug and 110 gr. of C&H powder.
Don't know if I'd have the ballz using a HP on grizz... probably feel more in my comfort zone with good penetration like the Gov't or a big 530gr slick from the Sharps, of course the full mag and fast cycling of the lever gun might be the ultimate game changer.
