Billiam280AI: C.O.A.L. is NOT the be all or end all to making accurate ammunition.
Your carefully made 22-250 handloads with LaPua brass in that quality arm "SHOULD" produce accuracy at the 2.350" measurement.
Try the 2.400" cartridges on a calm day and see how they group.
If there isn't much bullet body touching the neck of the case at 2,400" then that will show up.
I have PLENTY of target, Varmint and Big game Rifles where I seat my most accurate loadings and the bullet is no where near touching the leades of the rifling.
Having said that often it is EASIER to find accuracy with a particular bullet when it has little jump to the rifling.
In the last 20 years or so the "factory" Rifle makers have been VERY hesitant (it seems to me!) to chamber their Rifles with "short throats".
I have dealt with the "short magazine box" and "long throat" issues for some time now and its NOT a terminal, condition!
Best of luck and be sure to let us know how that Pro-Varmint shoots.
Hold into the wind
VarmintGuy