I would second the 375 H&H. Even a standard 270gr. Load would work. I shot a mule deer doe on a damage control hunt several years ago with a 375 Ruger with factory Hornady 270gr. Load out of my 20" barrel Guide Gun chronographed at 2770fps. 375H&H would be similar. 375 caliber entrance and 1-1/4" exit. 150yds. High shoulder shot. She went straight down and legs folded underneath her. Very little meat loss.375 H&H is almost same trajectory as a 30-06.
