You can drive a 55 gr. bullet pretty fast in the .22-250. My favorite load use to be a 55 gr. softpoint and 40 gr. of 760. That went 3850 fps in a Win model 70. When I got a Savage, the same load keyholed, so now I am shooting 40 gr. plastic tips with enough IMR4064 to hit 4,000 fps.