Yes you can, and I do just that except in the ever expanding Special regulations areas of Pa where it's rimfire only. I call fox the 22 Mag is a great round and will handle the stray Coyote. Sorry but I just don't trust a 17 to put down a Yote. Most of my calling is after dark so I want then dead right there. The Mag has never failed when I did my part.
Originally Posted by antelope_sniper
You can shoot .223 for the same price.

There are no problems that cannot be resolved by the suitable application of high explosive.