This is a tough one. I have both and on big chucks the 22-250 w/55gr. PSP out of a 12 twist hits hard. PA woodchuck hunting doesn't demand hot and heavy shooting. In my case, the 22-250 is a med. sporter weight walking varminter (Cooper M54 Jackson Game). Comparing this to my 26" heavy barreled Cooper M21 in 204. is apples to oranges. The 22-250 fouls out much faster, but I'm shooting a 32gr. moly coated VMAX in the 204. For shooting pdogs or in any other high volume scenario, the 22-250 wouldn't be in my top 5. In a walking PA woodchuck rifle, the 22-250 is a great choice.
