I have very little experience with the 6.5CM, ain't killed nothing with one yet. That said I have lots of time with a 250AI and I really, really like the 6.5CM. I currently have a Ruger Hawkeye SS in 6.5CM.
I think the 6.5CM is about the most well balanced factory cartridge introduced in a LONG time. One has to believe the barrel life with the 6.5 will be much better.
The next rifle I get screwed together will be a 6.5CM, but I'll be going short (21" barrel) and light with that one.