I am absolutely sold on Nanofil for spinning reels. It's just awesome.

I still have one or two spinning reels with 20# PowerPro, and it is fine. But when that gets replaced, it'll be with Nanofil.

I use PowerPro or Suffix on my casting reels with no complaints.

I use a 10-foot leader with braid, either mono or fluoro in a pound test to match the braid. Not only does the extra length mean I can do more reties before needing a new leader, but it also gives me a little stretch for cushion.

Cleverly disguised as a responsible adult.