If ultimate penetration for large game (elk, moose, etc.) is what you're looking for it's tough to beat cast bullets with a BRN hardness of 18-22.
The WFN LBT design in 400-460gr, gas checked and loaded around 1700 fps (45-70) is devastating. Full end to end penetration is possible if required.
Keep in mind on broadside shots one should aim at the shoulder and not behind for a double lung shot. A bull elk can go a long ways and get into some nasty spots with a double lung .458 caliber hole. You can still eat right up to the hole on a shoulder shot with a cast bullet.
On deer sized game just about anything will suffice and cast bullets can be overkill from a penetration standpoint although they are usually the cheapest option.
The 300gr Barnes TSX is an intriguing design and I've done some loading with it. I might be a little concerned for maximum penetration with the large frontal area they expand to while relatively light weight.
