Yep. And I would rate the "platform" as more important than the cartridge, especially if planning to hunt in a lot of different terrain and weather.
I have a custom 7mm Remington Magnum made on a 1909 Argentine action, with the original military trigger converted to a nice single-stage pull. The stock is made of fancy walnut, but with a lightweight synthetic stock, a front sight and a detachable aperture sight to fit the rear base of detachable scope mounts, it would definitely serve.
Then again, if I was going to do much more hunting of really big game (which I probably won't) either my very similar .338 on an FN Mauser action or my Mark X .375 H&H (which already has back-up irons) would also do.
A lot of it depends on what you plan to hunt. An all-around varmint/deer rifle isn't complicated. One centerfire for every kind of hunting on earth involves more compromises.
