I have used the 100 TTSX in my 257 Roberts to take a whitetail buck at close to 350 yards. Shot was broadside and the bullet enter about 2 ribs behind the shoulder (without hitting any ribs) an took out 1 rib as it exited. Deer ran at the shot but stopped at the 4 barb fence. A second shot was not possible from my original shooting position so I moved up skirting the edge of the field and found the buck running/stumbling toward me at about 100 yards and then piled up. Buck stayed on its feet for over 30 seconds and covered over 400 yards. Exit wound size of a quarter. I am currently loading TSX as I have had a couple of less than expected results from the TTSX in both .264 and .323 bullets also.
I had a muledeer hit through the lungs above the heart at about 100 yards away do that after being hit by a Nolser 7mm Partition 175. The muzzle velocity was 3,150 feet per second. The lungs were soup and yet the buck was not going to give up.
