If the 53 TSX doesn't work for ya, try the 45 as well. It's pretty brutal from a hornet from what I've heard.

I've never had an issue with standard 55 grain wally world bullets from a .22-250 on deer/antelope with tight behind the shoulder shots, but I am going to try the 62 TSX this year out of my 223. I got a tighter twist though.