I've only shot one deer with a 22-250. I used a 55 grain Winchester bullet, which was known not to expand much - I don't think that bullet is available as a reloading component any more, since that was in early 70's. I'm sure there's better bullets, but that one worked. If I were to try a 22-250 again, I'd look at Hornady, Core Lokt, and Nosler bullets.

I prefer classic.
Semper Fi
I used to run with the hare. Now I'm envious of the tortoise and I do my own stunts but rarely intentionally