Lots of good info here already, I have a 2.5-8 matte Leupold on my 375, it guides the 270 gr TSX's at 2780 fps to a 200 yard zero, it sits in steel Talley QD rings, the barrel iron sights are dead on at 50 yards with the 300 gr BBW #13 solids, BTW, the solids zeroed at 50 are on at 25 yards too, I can't tell/shoot/see any differences between the two yardages.
This is another combo that would work for all game anyone would point a 375 H&H mag at anywhere in the world.
