I have done this for many years. All my GWPs got the rattlesnake vaccine. While some say after the initial series of shots, the dog only need one shot a year. I opt to do two a year. I also have put them through snake avoidance training. My neighbor has done the same with his two GSPs.

My vet Dr. Michael Robinson, Tucson Az, has treated in the neighborhood of 100 dogs that had the vaccine and had been bitten. None required antivenom. He is very outspoken as to the benefits of the vaccine.

Point of information: it doesn't work on mohave rattlers which have both neuro and hemo toxins.