IIRC, 300 NPT's in the .375 H&H had a less than stellar reputation on DG. Don't remember the details. Maybe someone with a better memory could comment.
Maybe on lighter critters they'd be OK.
DF
They can be stopped by moose...
And even if they're only twice as good as a cup and core, that still doesn't make an Interlock a better choice.
I wouldn't hesitate to use them on anything in Alaska.