I'm with Flave on this one. Get a brake put on the -06 and she'll be good to go. Will reduce felt recoil to something like a .243. Use a 180gr. TSX or similar and she should have good penetration. I would think Phil Shoemaker would probably have some good words of wisdom on this since he's dealt with a huge variety of hunters over the years and his wife and daughter could probably give some advice as well.
