I hunted squirrels a lot as a kid in Lavaca co., TX, almost 100% fox squirrels. Now I have grays as my target in SE VA. Use a scattergun mostly, I have 3 rifle kills with 3 shots lifetime. One was a .38 WCF, one was a .257 Roberts, and the last was a .35 Remington. Never tried a .22, maybe this year would be a good time to try one.