We have 2003 F350 that only has about 120k on it but has been to hell and back.
It's literally wore out and doesn't go too far from home. Not worth much but it's a good backup feed pickup.
I drive a 2003 F350(140k miles/6.0) and the way I use it, it'll be good for at least another 140k miles.
Wife's '11 Explorer has 16-18k miles.
