I don't know if it is valid, but I recall reading a minimum magical energy number for game. I think deer is 800fpe, and elk might be 1000 or 1200. Anyway, heavier projectiles have and hold more energy out of a ML. It might be BS, but I respect the 800 number as a goal for deer. I really dont like recoil, but I try to keep the energy up that area.
I know guys kill moose with 22s, but I like to have more than a minimum for any game. I think 50 ball is OK, but more is probably not overkill.